ZNF658

Across TCGA patient cohorts, ZNF658 mutation is significantly associated with the total protein of many other genes, with 45 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF658-associated genes across cancer lineages are 4E-BP1_pT70, p62 Lck ligand, and 4E-BP1. Each is linked with ZNF658 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF658-to-partner and partner-to-ZNF658 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1_pT70 grouped by ZNF658-low versus ZNF658-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF658→partner) and Y-score (partner→ZNF658) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	4E-BP1_pT70 →	+0.176	+3.467	.001	.002	3	3
UCEC	p62 Lck ligand →	+0.407	+2.672	<.001	<.001	3	3
UCEC	4E-BP1 →	+0.366	+2.906	<.001	.001	3	3
UCEC	PDCD4 →	-0.426	-2.222	.004	.009	3	2
COAD	C-Raf →	+0.164	+2.330	.013	.020	3	2
UCEC	JNK2 →	+0.187	+1.777	.003	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 45 associations by consensus.

4E-BP1_pT70 by ZNF658 expression — COAD

Explore this box plot interactively →