ZNF658

Across TCGA pan-cancer cohorts, ZNF658 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF658’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF658 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF658 is over-expressed in tumor, although a few such as THCA and COAD show the opposite, repressed pattern.

THCA, COAD, and KICH are the cancer types where ZNF658 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF658 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−1.055	<.001	11	view →
COAD	All	II,III,IV	−0.289	<.001	9	view →
KICH	Male	All	−0.734	<.001	8	view →
LUAD	Female	III,IV	−0.458	<.001	8	view →
BRCA	All	III,IV	−0.565	<.001	6	view →
LIHC	Male	All	+0.273	<.001	5	view →
UCEC	All	All	−0.679	<.001	4	view →
CHOL	All	All	+0.647	.001	2	view →
PAAD	Female	All	−0.455	.040	2	view →
PRAD	All	All	−0.217	.013	2	view →
LUSC	All	All	+0.227	.017	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF658–THCA

Open the THCA breakdown →