ZNF653

Across TCGA patient cohorts, ZNF653 mutation is significantly associated with the RNA expression of many other genes, with 1,210 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF653-associated genes across cancer lineages are ENPP3, SKA1, and MAB21L4. Each is linked with ZNF653 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF653-to-partner and partner-to-ZNF653 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ENPP3 grouped by ZNF653-low versus ZNF653-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF653→partner) and Y-score (partner→ZNF653) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ENPP3 →	-1.256	-3.700	.005	.001	3	2
UCEC	SKA1 →	+0.612	+2.595	.003	<.001	3	2
UCEC	MAB21L4 →	-1.224	-2.898	<.001	.001	3	2
UCEC	TIMM21 →	+0.441	+2.595	.004	<.001	3	2
UCEC	TXNL1 →	+0.364	+2.087	.008	.006	3	2
CESC	TTTY12 →	+0.055	+5.397	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,210 associations by consensus.

ENPP3 by ZNF653 expression — UCEC

Explore this box plot interactively →