ZNF653

Across TCGA pan-cancer cohorts, ZNF653 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of ZNF653’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF653 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF653 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

KIRC, KICH, and LIHC are the cancer types where ZNF653 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF653 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Female	All	+0.618	<.001	11	view →
KICH	All	III,IV	−0.851	<.001	9	view →
LIHC	Female	II,III,IV	+0.756	<.001	9	view →
COAD	Female	All	+0.568	<.001	9	view →
THCA	Male	IV	−0.646	.001	8	view →
HNSC	Male	III,IV	+0.541	<.001	8	view →
STAD	Male	II,III,IV	+0.747	<.001	6	view →
READ	Male	All	+0.383	.029	5	view →
BRCA	All	All	+0.226	.004	4	view →
CHOL	All	All	+1.533	<.001	3	view →
ESCA	All	All	+0.437	.015	2	view →
LUAD	All	All	−0.186	.015	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

ZNF653–KIRC

Open the KIRC breakdown →