ZNF653

Across TCGA patient cohorts, ZNF653 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF653-associated genes across cancer lineages are ATM, MEK1, and ERK2. Each is linked with ZNF653 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF653-to-partner and partner-to-ZNF653 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF653-low versus ZNF653-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF653→partner) and Y-score (partner→ZNF653) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.741	-2.807	<.001	.003	3	3
UCEC	MEK1 →	+0.554	+3.906	<.001	<.001	3	2
UCEC	ERK2 →	+0.196	+2.115	.019	.019	3	1
UCEC	GSK-3a-b_pS21_S9 →	+0.509	+2.009	.006	.017	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.559	+3.179	.011	.010	3	1
UCEC	JNK_pT183_Y185 →	-0.225	-2.102	.002	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ATM by ZNF653 expression — UCEC

Explore this box plot interactively →