ZNF653

Across TCGA cell cohorts, ZNF653 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,781 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF653-associated GO terms across cancer lineages are Positive regulation of anaphase-promoting complex-dependent catabolic process, Negative regulation of DNA-templated transcription initiation, and Negative regulation of transcription initiation by RNA polymerase II. Each is linked with ZNF653 in more than 16 cancer types. Because this analysis shows association rather than direction, both ZNF653-to-partner and partner-to-ZNF653 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of anaphase-promoting complex-dependent catabolic process grouped by ZNF653-low versus ZNF653-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF653→partner) and Y-score (partner→ZNF653) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Positive regulation of anaphase-promoting complex-dependent catabolic process →	+0.140	+0.899	<.001	<.001	3	17
PANCREAS	Negative regulation of DNA-templated transcription initiation →	+0.138	+1.170	<.001	<.001	3	15
PANCREAS	Negative regulation of transcription initiation by RNA polymerase II →	+0.138	+1.170	<.001	<.001	3	15
PANCREAS	Negative regulation of protein localization to chromatin →	+0.155	+0.827	<.001	<.001	3	15
PANCREAS	Regulation of protein localization to chromatin →	+0.103	+0.663	.002	.003	3	15
LARGE_INTESTINE	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.162	+0.883	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,781 associations by consensus.

Positive regulation of anaphase-promoting complex-dependent catabolic process by ZNF653 expression — BONE

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