ZNF653

Across TCGA cell cohorts, ZNF653 mutation is significantly associated with the RNA expression of many other genes, with 8 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible ZNF653-associated genes across cancer lineages are PRND, DIP2C-AS1, and TEX43. Each is linked with ZNF653 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF653-to-partner and partner-to-ZNF653 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRND grouped by ZNF653-low versus ZNF653-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF653→partner) and Y-score (partner→ZNF653) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	PRND →	+0.009	+3.874	<.001	.005	3	1
BLOOD_Leukemia	DIP2C-AS1 →	+0.145	+3.896	<.001	.006	3	1
BLOOD_Leukemia	TEX43 →	+0.084	+4.384	<.001	.006	3	1
LUNG_NSCLC_LUAD	SIGLEC5 →	+0.349	+4.803	<.001	<.001	3	1
LUNG_NSCLC_LUAD	GABRA6 →	+0.063	+3.604	<.001	.004	3	1
LUNG_NSCLC_LUAD	RGR →	+0.020	+3.481	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

PRND by ZNF653 expression — BLOOD_Leukemia

Explore this box plot interactively →