Across TCGA patient cohorts, ZNF649 protein abundance is significantly associated with the RNA expression of many other genes, with 2,126 significant associations in total. GBM shows the largest number of these associations.

The most reproducible ZNF649-associated genes across cancer lineages are SHC3, ZNF577, and RCAN2. Each is linked with ZNF649 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF649-to-partner and partner-to-ZNF649 results are reported.

Each partner links to its own Q-omics profile.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF649→partner) and Y-score (partner→ZNF649) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	SHC3 →	+0.959	+0.562	<.001	<.001	3	3
BRCA	ZNF577 →	+1.022	+0.790	.004	.005	3	3
UCEC	RCAN2 →	+0.712	+0.324	.001	.005	3	2
PDAC	HPCAL1 →	-1.119	-0.961	.002	.004	3	2
PDAC	SLC39A11 →	-1.173	-1.093	.001	<.001	3	2
GBM	REV3L-IT1 →	+0.675	+0.560	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,126 associations by consensus.

Exploration

ZNF649 survival (RNA) · tumor vs normal (RNA) · all ZNF649 data types