ZNF649-AS1

Across TCGA pan-cancer cohorts, ZNF649-AS1 RNA is linked to patient survival in 21 of 34 cancer types, making it the most broadly survival-associated ZNF649-AS1 data layer.

The strongest signal is observed in brain lower grade glioma (LGG), where higher ZNF649-AS1 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF649-AS1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and ESCA show a favorable association.

LGG, BRCA, and LIHC are the cancer types where ZNF649-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LGG	DFS	Median	All	0.317	0.489	<.001	43	view →
BRCA	OS	Median	All	0.518	0.632	.001	40	view →
LIHC	OS	Quartile	II,III,IV	0.473	0.806	<.001	31	view →
THCA	DFS	Quartile	II,III,IV	0.596	0.863	.013	23	view →
ACC	DFS	Median	II,III,IV	0.525	0.710	.021	21	view →
HNSC	DFS	Quartile	IV	0.424	0.232	.002	18	view →
SARC	DFS	Quartile	All	0.475	0.738	.016	13	view →
ESCA	DFS	Median	II,III,IV	1.000	0.388	.010	12	view →
CHOL	DFS	Median	III,IV	0.127	0.647	.006	9	view →
LUSC	DFS	Tertile	III,IV	0.407	0.822	.045	9	view →
BLCA	DFS	Median	III,IV	0.506	0.631	.018	6	view →
GBM	DFS	Median	All	0.377	0.198	.009	6	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 21 lineages.

ZNF649-AS1–LGG (DFS)

Open the LGG breakdown →