ZNF649-AS1

Across TCGA pan-cancer cohorts, ZNF649-AS1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF649-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF649-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF649-AS1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

HNSC, KIRP, and KICH are the cancer types where ZNF649-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF649-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.293	.001	5	view →
KIRP	Male	II,III,IV	+0.208	.025	5	view →
KICH	All	All	−0.201	<.001	5	view →
STAD	All	All	+0.192	.010	4	view →
BRCA	Female	All	+0.150	.004	4	view →
LIHC	All	All	+0.102	<.001	4	view →
LUSC	All	All	+0.268	.002	3	view →
KIRC	All	All	+0.080	.023	3	view →
PRAD	All	All	+0.750	<.001	2	view →
LUAD	Male	All	+0.324	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZNF649-AS1–HNSC

Open the HNSC breakdown →