ZNF648

Across TCGA cell cohorts, ZNF648 mutation is significantly associated with the RNA expression of many other genes, with 1,053 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF648-associated genes across cancer lineages are CT45A6, IL9, and OR4E1. Each is linked with ZNF648 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF648-to-partner and partner-to-ZNF648 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CT45A6 grouped by ZNF648-low versus ZNF648-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF648→partner) and Y-score (partner→ZNF648) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	CT45A6 →	+0.099	+4.906	<.001	.006	3	1
LUNG_NSCLC_LUAD	IL9 →	+0.040	+5.228	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR4E1 →	+0.013	+6.266	<.001	<.001	3	1
BLOOD_Lymphoma	SPATA31A6 →	+0.029	+5.643	<.001	.002	3	1
BLOOD_Lymphoma	USP17L4 →	+0.013	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	LYZL6 →	+0.040	+5.643	.005	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,053 associations by consensus.

CT45A6 by ZNF648 expression — OESOPHAGUS

Explore this box plot interactively →