ZNF646

Across TCGA patient cohorts, ZNF646 mutation is significantly associated with the RNA expression of many other genes, with 5,100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF646-associated genes across cancer lineages are SKA1, ERP27, and EXOSC9. Each is linked with ZNF646 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF646-to-partner and partner-to-ZNF646 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SKA1 grouped by ZNF646-low versus ZNF646-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF646→partner) and Y-score (partner→ZNF646) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SKA1 →	+0.755	+1.936	<.001	<.001	3	4
UCEC	ERP27 →	-1.127	-1.739	<.001	<.001	3	4
UCEC	EXOSC9 →	+0.402	+1.771	<.001	<.001	3	4
UCEC	CDCA2 →	+0.787	+2.321	<.001	<.001	3	4
STAD	MRPS33 →	+0.462	+3.857	<.001	<.001	3	4
UCEC	TAF9 →	+0.667	+2.115	<.001	<.001	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,100 associations by consensus.

SKA1 by ZNF646 expression — UCEC

Explore this box plot interactively →