ZNF646

Across TCGA pan-cancer cohorts, ZNF646 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated ZNF646 data layer compared with 11 for mutation status and 3 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF646 RNA is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF646 expression acts as an unfavorable survival marker, although some lineages such as HNSC and KIRC show a favorable association.

HNSC, KIRC, and LIHC are the cancer types where ZNF646 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Tertile	IV	0.722	0.512	<.001	80	view →
KIRC	DFS	Tertile	All	0.777	0.510	.001	55	view →
LIHC	DFS	Tertile	All	0.432	0.607	<.001	45	view →
UCS	OS	Median	IV	0.732	0.224	.018	24	view →
ACC	DFS	Quartile	All	0.475	0.832	.005	23	view →
LUSC	DFS	Tertile	III,IV	0.454	1.000	.003	22	view →
THYM	OS	Median	All	0.955	0.748	.009	21	view →
LUAD	OS	Median	II,III,IV	0.166	0.425	.016	20	view →
COAD	OS	Tertile	All	0.748	0.901	.005	16	view →
MESO	DFS	Median	All	0.299	0.426	.020	15	view →
PAAD	OS	Quartile	II,III,IV	0.635	0.364	.005	13	view →
SKCM	OS	Median	All	0.829	0.904	.017	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

ZNF646–HNSC (DFS)

Open the HNSC breakdown →