ZNF646

Across TCGA patient cohorts, ZNF646 mutation is significantly associated with the total protein of many other genes, with 69 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF646-associated genes across cancer lineages are 4E-BP1, PCNA, and FOXO3a_pS318_S321. Each is linked with ZNF646 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF646-to-partner and partner-to-ZNF646 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 4E-BP1 grouped by ZNF646-low versus ZNF646-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF646→partner) and Y-score (partner→ZNF646) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	4E-BP1 →	+0.350	+3.392	<.001	<.001	3	4
UCEC	PCNA →	+0.244	+1.917	<.001	<.001	3	3
UCEC	FOXO3a_pS318_S321 →	-0.087	-1.706	.011	.003	3	3
UCEC	JNK_pT183_Y185 →	-0.140	-1.652	.002	.005	3	3
UCEC	TIGAR →	+0.151	+1.944	<.001	<.001	3	3
UCEC	Cyclin-E2 →	+0.121	+1.087	.009	.048	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 69 associations by consensus.

4E-BP1 by ZNF646 expression — UCEC

Explore this box plot interactively →