ZNF646

Across TCGA cell cohorts, ZNF646 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,842 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible ZNF646-associated GO terms across cancer lineages are Positive regulation of intracellular steroid hormone receptor signaling pathway, Positive regulation of intracellular estrogen receptor signaling pathway, and Negative regulation of syncytium formation by plasma membrane fusion. Each is linked with ZNF646 in more than 16 cancer types. Because this analysis shows association rather than direction, both ZNF646-to-partner and partner-to-ZNF646 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Positive regulation of intracellular steroid hormone receptor signaling pathway grouped by ZNF646-low versus ZNF646-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF646→partner) and Y-score (partner→ZNF646) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	Positive regulation of intracellular steroid hormone receptor signaling pathway →	+0.136	+0.897	<.001	<.001	3	17
BONE	Positive regulation of intracellular estrogen receptor signaling pathway →	+0.198	+0.806	<.001	<.001	3	17
STOMACH	Negative regulation of syncytium formation by plasma membrane fusion →	+0.132	+0.838	<.001	<.001	3	17
UPPER_AERODIGESTIVE_TRACT	Negative regulation of myoblast fusion →	+0.125	+0.856	<.001	<.001	3	17
SOFT_TISSUE	Positive regulation of T-helper 17 cell lineage commitment →	+0.209	+1.021	<.001	<.001	3	17
OESOPHAGUS	Regulation of mRNA splicing, via spliceosome →	+0.095	+1.182	.007	.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,842 associations by consensus.

Positive regulation of intracellular steroid hormone receptor signaling pathway by ZNF646 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →