ZNF646

Across TCGA cell cohorts, ZNF646 mutation is significantly associated with the RNA expression of many other genes, with 355 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF646-associated genes across cancer lineages are BCL7A, PPP2R5D, and TTC19. Each is linked with ZNF646 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF646-to-partner and partner-to-ZNF646 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, BCL7A grouped by ZNF646-low versus ZNF646-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF646→partner) and Y-score (partner→ZNF646) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	BCL7A →	+0.793	+3.321	.001	.003	3	2
LARGE_INTESTINE	PPP2R5D →	+0.540	+3.064	.005	.009	3	2
LARGE_INTESTINE	TTC19 →	+0.616	+3.169	.001	.006	3	2
LARGE_INTESTINE	ID3 →	+2.053	+3.087	.001	.006	3	2
LARGE_INTESTINE	HAUS8 →	+0.422	+2.743	.007	.001	3	2
LARGE_INTESTINE	CDCA8 →	+0.461	+2.043	.008	.008	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 355 associations by consensus.

BCL7A by ZNF646 expression — LARGE_INTESTINE

Explore this box plot interactively →