ZNF644

Across TCGA patient cohorts, ZNF644 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF644-associated genes across cancer lineages are Rad50, 14-3-3_beta, and JNK2. Each is linked with ZNF644 in more than 2 cancer types. Because this analysis shows association rather than direction, both ZNF644-to-partner and partner-to-ZNF644 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Rad50 grouped by ZNF644-low versus ZNF644-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF644→partner) and Y-score (partner→ZNF644) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Rad50 →	-0.181	-2.074	.008	.004	3	3
UCEC	14-3-3_beta →	-0.065	-1.388	.023	.041	3	2
UCEC	JNK2 →	+0.148	+1.054	.008	.029	3	2
UCEC	MEK1 →	+0.279	+1.652	.007	.005	3	2
COAD	p62 Lck ligand →	+0.431	+2.815	.042	.036	3	2
UCEC	PCNA →	+0.187	+2.321	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Rad50 by ZNF644 expression — UCEC

Explore this box plot interactively →