ZNF644

Across TCGA pan-cancer cohorts, ZNF644 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF644’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF644 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF644 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

THCA, HNSC, and STAD are the cancer types where ZNF644 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF644 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	All	II,III,IV	−0.808	<.001	8	view →
HNSC	All	All	+0.425	<.001	8	view →
STAD	All	II,III,IV	+0.653	.001	6	view →
LIHC	All	All	+0.496	<.001	6	view →
KICH	Female	All	−0.962	<.001	5	view →
BLCA	All	III,IV	+0.501	.020	5	view →
LUAD	Male	All	+0.601	<.001	4	view →
CHOL	Female	All	+1.570	<.001	3	view →
ESCA	Female	All	+0.900	.015	2	view →
LUSC	All	All	+0.231	.012	2	view →
KIRC	All	All	+0.176	.040	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF644–THCA

Open the THCA breakdown →