ZNF622

Across TCGA pan-cancer cohorts, ZNF622 mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF622 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZNF622 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF622 expression acts as an unfavorable survival marker, although some lineages such as PDAC show a favorable association.

CCRCC, GBM, and PDAC are the cancer types where ZNF622 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Quartile	All	0.347	1.000	.002	14	view →
GBM	DFS	Tertile	All	0.587	0.834	.002	14	view →
PDAC	DFS	Median	IV	0.785	0.214	.006	9	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF622–CCRCC (DFS)

Open the CCRCC breakdown →