ZNF622

Across TCGA pan-cancer cohorts, ZNF622 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZNF622’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where ZNF622 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF622 is over-expressed in tumor, although a few such as READ and KICH show the opposite, repressed pattern.

HNSC, KIRC, and LIHC are the cancer types where ZNF622 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF622 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+0.837	<.001	12	view →
KIRC	Male	IV	+0.818	<.001	12	view →
LIHC	Male	II,III,IV	+1.026	<.001	8	view →
STAD	All	II,III,IV	+0.740	<.001	8	view →
LUAD	All	III,IV	+0.642	<.001	7	view →
BRCA	All	II,III,IV	+0.295	<.001	6	view →
CHOL	All	All	+1.423	<.001	5	view →
LUSC	Male	All	+0.627	<.001	5	view →
KIRP	All	II,III,IV	+0.547	.001	5	view →
BLCA	All	III,IV	+0.431	.022	3	view →
THCA	Male	III,IV	+0.341	.006	3	view →
COAD	All	All	+0.244	.008	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZNF622–HNSC

Open the HNSC breakdown →