ZNF622

Across TCGA cell cohorts, ZNF622 mutation is significantly associated with the RNA expression of many other genes, with 12 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF622-associated genes across cancer lineages are IL21, AVP, and CABP5. Each is linked with ZNF622 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF622-to-partner and partner-to-ZNF622 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by ZNF622-low versus ZNF622-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF622→partner) and Y-score (partner→ZNF622) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	IL21 →	+0.012	+4.887	<.001	.009	3	1
BLOOD_Lymphoma	AVP →	+0.031	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	CABP5 →	+0.012	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	DEFB129 →	+0.043	+6.247	<.001	<.001	3	1
BLOOD_Lymphoma	REG3G →	+0.040	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	KLHL40 →	+0.013	+5.209	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 12 associations by consensus.

IL21 by ZNF622 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →