ZNF622

Across TCGA cell cohorts, ZNF622 mutation is significantly associated with the mutation status of many other genes, with 2,940 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF622-associated genes across cancer lineages are DGKI, ARFGEF2, and ZBTB41. Each is linked with ZNF622 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF622-to-partner and partner-to-ZNF622 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DGKI grouped by ZNF622-low versus ZNF622-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF622→partner) and Y-score (partner→ZNF622) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	DGKI →	+4.014	+4.969	.008	.008	1	4
LARGE_INTESTINE	ARFGEF2 →	+2.574	+4.182	.003	.003	1	4
UPPER_AERODIGESTIVE_TRACT	ZBTB41 →	+5.392	+5.392	.004	.004	1	3
LUNG_NSCLC_LUAD	SND1 →	+4.339	+4.339	.009	.009	1	3
LUNG_NSCLC_LUAD	PIGN →	+4.339	+4.339	.009	.009	1	3
UPPER_AERODIGESTIVE_TRACT	ERCC6L2 →	+5.392	+5.392	.004	.004	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,940 associations by consensus.

DGKI by ZNF622 expression — BLOOD_Lymphoma

Explore this box plot interactively →