ZNF621

Across TCGA cell cohorts, ZNF621 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,191 significant associations in total. BONE shows the largest number of these associations.

The most reproducible ZNF621-associated GO terms across cancer lineages are R-loop processing, Cytosolic transport, and Positive regulation of pinocytosis. Each is linked with ZNF621 in more than 12 cancer types. Because this analysis shows association rather than direction, both ZNF621-to-partner and partner-to-ZNF621 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, R-loop processing grouped by ZNF621-low versus ZNF621-high in UPPER_AERODIGESTIVE_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF621→partner) and Y-score (partner→ZNF621) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	R-loop processing →	+0.102	+1.069	<.001	.001	3	13
BONE	Cytosolic transport →	+0.084	+1.101	<.001	<.001	3	12
KIDNEY	Positive regulation of pinocytosis →	+0.111	+0.873	.002	<.001	3	12
URINARY_TRACT	Negative regulation of telomere maintenance →	+0.107	+1.062	<.001	<.001	2	13
OVARY	Regulation of macroautophagy →	+0.057	+0.836	<.001	<.001	3	11
KIDNEY	Peptidyl-serine phosphorylation →	+0.098	+0.952	.001	.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,191 associations by consensus.

R-loop processing by ZNF621 expression — UPPER_AERODIGESTIVE_TRACT

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