ZNF621

Across TCGA cell cohorts, ZNF621 mutation is significantly associated with the RNA expression of many other genes, with 5 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF621-associated genes across cancer lineages are C6orf118, TMCO5A, and OR4A47. Each is linked with ZNF621 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF621-to-partner and partner-to-ZNF621 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C6orf118 grouped by ZNF621-low versus ZNF621-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF621→partner) and Y-score (partner→ZNF621) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	C6orf118 →	+0.171	+3.793	<.001	.007	3	1
LARGE_INTESTINE	TMCO5A →	+0.024	+5.000	<.001	<.001	3	1
LARGE_INTESTINE	OR4A47 →	+0.018	+4.437	<.001	.004	3	1
BLOOD_Leukemia	OR51T1 →	+0.071	+4.922	<.001	.009	3	1
BLOOD_Leukemia	GSG1L2 →	+0.058	+5.969	<.001	.001	3	1

Each partner links to its Q-omics profile. Showing the 5 strongest of 5 associations by consensus.

C6orf118 by ZNF621 expression — LARGE_INTESTINE

Explore this box plot interactively →