ZNF606

Across TCGA cell cohorts, ZNF606 mutation is significantly associated with the RNA expression of many other genes, with 63 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF606-associated genes across cancer lineages are GIPC2, RBMY1F, and PRAMEF7. Each is linked with ZNF606 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF606-to-partner and partner-to-ZNF606 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIPC2 grouped by ZNF606-low versus ZNF606-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF606→partner) and Y-score (partner→ZNF606) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	GIPC2 →	+1.551	+2.850	<.001	<.001	3	2
URINARY_TRACT	RBMY1F →	+0.266	+5.087	<.001	.004	3	1
URINARY_TRACT	PRAMEF7 →	+0.043	+5.087	<.001	.004	3	1
SKIN	SLC7A10 →	+0.177	+2.832	<.001	.002	3	1
SKIN	STX17 →	+0.569	+3.067	.008	.009	3	1
SKIN	TAT →	+0.027	+3.479	.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 63 associations by consensus.

GIPC2 by ZNF606 expression — LARGE_INTESTINE

Explore this box plot interactively →