ZNF598

Across TCGA pan-cancer cohorts, ZNF598 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ZNF598 data layer compared with 21 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher ZNF598 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF598 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LUAD show a favorable association.

HNSC, PDAC, and LUAD are the cancer types where ZNF598 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	1.000	0.393	.018	37	view →
PDAC	DFS	Median	IV	0.214	0.785	.006	16	view →
LUAD	DFS	Tertile	III,IV	0.968	0.471	.031	11	view →
UCEC	DFS	Quartile	All	0.817	0.971	.045	2	view →
GBM	OS	Quartile	All	0.719	0.979	.036	2	view →
LSCC	DFS	Tertile	III,IV	0.443	0.814	.040	2	view →
CCRCC	DFS	Median	IV	0.932	0.382	.031	1	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ZNF598–HNSC (DFS)

Open the HNSC breakdown →