ZNF598

Across TCGA pan-cancer cohorts, ZNF598 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZNF598’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZNF598 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF598 is over-expressed in tumor.

COAD, HNSC, and KIRP are the cancer types where ZNF598 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF598 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	+1.560	<.001	12	view →
HNSC	Male	All	+1.108	<.001	12	view →
KIRP	All	III,IV	+1.205	<.001	11	view →
KIRC	Female	All	+0.724	<.001	11	view →
LUAD	All	III,IV	+1.032	<.001	9	view →
LIHC	All	III,IV	+0.973	<.001	9	view →
STAD	Male	II,III,IV	+1.180	<.001	8	view →
LUSC	Male	II,III,IV	+1.158	<.001	7	view →
UCEC	All	III,IV	+0.713	.011	6	view →
BRCA	All	All	+0.507	<.001	6	view →
CHOL	Male	All	+1.718	<.001	5	view →
READ	Female	All	+1.253	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZNF598–COAD

Open the COAD breakdown →