ZNF598

Across TCGA patient cohorts, ZNF598 mutation is significantly associated with the total protein of many other genes, with 26 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF598-associated genes across cancer lineages are ERK2, IGFBP2, and JNK2. Each is linked with ZNF598 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF598-to-partner and partner-to-ZNF598 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by ZNF598-low versus ZNF598-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF598→partner) and Y-score (partner→ZNF598) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.253	+2.392	<.001	<.001	3	1
UCEC	IGFBP2 →	-0.805	-2.222	<.001	.009	3	1
UCEC	JNK2 →	+0.194	+2.125	.005	.010	3	1
UCEC	Lck →	+0.201	+1.362	.004	.037	3	1
UCEC	MEK1 →	+0.265	+1.700	.040	.042	3	1
UCEC	MSH2 →	-0.310	-2.196	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 26 associations by consensus.

ERK2 by ZNF598 expression — UCEC

Explore this box plot interactively →