ZNF598

Across TCGA cell cohorts, ZNF598 mutation is significantly associated with the RNA expression of many other genes, with 390 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF598-associated genes across cancer lineages are MGARP, SLC18B1, and ROBO3. Each is linked with ZNF598 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF598-to-partner and partner-to-ZNF598 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MGARP grouped by ZNF598-low versus ZNF598-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF598→partner) and Y-score (partner→ZNF598) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MGARP →	+0.108	+2.743	.002	.001	3	2
LARGE_INTESTINE	SLC18B1 →	+0.743	+3.169	.002	.006	3	2
LARGE_INTESTINE	ROBO3 →	+1.010	+2.459	.008	.006	3	2
LARGE_INTESTINE	NKX3-1 →	+0.871	+3.404	.002	<.001	3	2
LARGE_INTESTINE	PTTG2 →	+0.071	+2.497	<.001	.001	3	2
LUNG_NSCLC_LUAD	GPR101 →	+0.022	+4.887	<.001	.009	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 390 associations by consensus.

MGARP by ZNF598 expression — LARGE_INTESTINE

Explore this box plot interactively →