ZNF595

Across TCGA patient cohorts, ZNF595 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF595-associated genes across cancer lineages are C-Raf, EGFR_pY1068, and eIF4E. Each is linked with ZNF595 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF595-to-partner and partner-to-ZNF595 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ZNF595-low versus ZNF595-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF595→partner) and Y-score (partner→ZNF595) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.126	+1.678	.010	.021	3	2
UCEC	EGFR_pY1068 →	-0.193	-1.514	.024	.015	3	1
UCEC	eIF4E →	+0.148	+3.013	.039	.018	3	1
UCEC	ER-alpha_pS118 →	-0.258	-2.700	.035	.006	3	1
UCEC	ER-alpha →	-0.614	-1.807	.028	.025	3	1
UCEC	A-Raf_pS299 →	-0.101	-2.321	.012	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

C-Raf by ZNF595 expression — UCEC

Explore this box plot interactively →