ZNF595

Across TCGA pan-cancer cohorts, ZNF595 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF595’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where ZNF595 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF595 is over-expressed in tumor, although a few such as THCA and STAD show the opposite, repressed pattern.

THCA, KIRC, and LIHC are the cancer types where ZNF595 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF595 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	−0.804	<.001	11	view →
KIRC	Female	All	+0.493	<.001	9	view →
LIHC	Female	All	+0.682	<.001	8	view →
STAD	All	II,III,IV	−0.772	<.001	6	view →
COAD	Female	All	−0.725	<.001	6	view →
READ	All	II,III,IV	−0.862	.004	5	view →
CHOL	Male	All	+0.883	.003	2	view →
UCEC	All	All	−0.498	.026	2	view →
PRAD	All	All	+0.398	<.001	2	view →
LUSC	Female	III,IV	−0.384	.032	2	view →
BRCA	Female	All	−0.172	.024	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF595–THCA

Open the THCA breakdown →