ZNF593

Across TCGA pan-cancer cohorts, ZNF593 mass-spec protein is linked to patient survival in 7 of 34 cancer types, making it a survival-associated ZNF593 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher ZNF593 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF593 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

LUAD, CCRCC, and UCEC are the cancer types where ZNF593 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	DFS	Median	II,III,IV	0.193	0.699	.016	9	view →
CCRCC	DFS	Quartile	III,IV	0.392	0.885	.002	9	view →
UCEC	DFS	Quartile	All	1.000	0.824	.032	8	view →
PDAC	DFS	Quartile	All	0.986	0.729	.008	5	view →
LSCC	DFS	Quartile	II,III,IV	0.535	0.904	.010	3	view →
HNSC	OS	Tertile	All	1.000	0.924	.022	3	view →
GBM	OS	Tertile	All	0.546	0.327	.033	2	view →

Pink = unfavorable, green = favorable. Showing the 7 strongest of 7 lineages.

ZNF593–LUAD (DFS)

Open the LUAD breakdown →