ZNF589

Across TCGA patient cohorts, ZNF589 mutation is significantly associated with the RNA expression of many other genes, with 2,156 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF589-associated genes across cancer lineages are MIR4441, RN7SL248P, and CMC1. Each is linked with ZNF589 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF589-to-partner and partner-to-ZNF589 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR4441 grouped by ZNF589-low versus ZNF589-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF589→partner) and Y-score (partner→ZNF589) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	MIR4441 →	+0.699	+4.665	<.001	.001	3	2
UCEC	RN7SL248P →	+0.051	+2.915	<.001	.007	3	2
UCEC	CMC1 →	+0.292	+2.136	.008	.009	3	2
UCEC	ERI2 →	+0.428	+1.936	.003	.003	3	2
UCEC	RNU2-51P →	+0.393	+1.704	<.001	.003	3	2
UCEC	GHRLOS →	+0.830	+3.459	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,156 associations by consensus.

MIR4441 by ZNF589 expression — COAD

Explore this box plot interactively →