ZNF587B

Across TCGA patient cohorts, ZNF587B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF587B-associated genes across cancer lineages are INPP4B, EGFR_pY1068, and ERK2. Each is linked with ZNF587B in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF587B-to-partner and partner-to-ZNF587B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, INPP4B grouped by ZNF587B-low versus ZNF587B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF587B→partner) and Y-score (partner→ZNF587B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	INPP4B →	-0.351	-3.321	.008	.009	3	2
UCEC	EGFR_pY1068 →	-0.215	-3.169	.037	.018	3	1
UCEC	ERK2 →	+0.176	+2.321	.026	.033	3	1
UCEC	MAPK_pT202_Y204 →	-0.452	-2.000	.019	.030	3	1
UCEC	MEK1 →	+0.401	+2.321	.007	.006	3	1
UCEC	Notch1 →	+0.132	+2.331	.023	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

INPP4B by ZNF587B expression — UCEC

Explore this box plot interactively →