ZNF587B

Across TCGA pan-cancer cohorts, ZNF587B RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ZNF587B’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZNF587B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF587B is over-expressed in tumor, although a few such as KIRP and THCA show the opposite, repressed pattern.

LIHC, BLCA, and STAD are the cancer types where ZNF587B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF587B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.846	<.001	9	view →
BLCA	All	III,IV	+0.581	.003	9	view →
STAD	Male	II,III,IV	+1.037	<.001	8	view →
COAD	Male	All	+0.704	<.001	8	view →
LUAD	All	All	+0.537	<.001	8	view →
HNSC	All	All	+0.340	.002	7	view →
BRCA	All	III,IV	+0.781	<.001	6	view →
UCEC	All	III,IV	+0.715	.019	6	view →
KIRP	Male	All	−0.649	<.001	6	view →
THCA	All	All	−0.358	<.001	6	view →
CHOL	Male	All	+1.788	<.001	5	view →
KICH	Male	II,III,IV	−0.887	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ZNF587B–LIHC

Open the LIHC breakdown →