ZNF586

Across TCGA patient cohorts, ZNF586 mutation is significantly associated with the total protein of many other genes, with 29 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF586-associated genes across cancer lineages are C-Raf, FoxM1, and FOXO3a_pS318_S321. Each is linked with ZNF586 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF586-to-partner and partner-to-ZNF586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, C-Raf grouped by ZNF586-low versus ZNF586-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF586→partner) and Y-score (partner→ZNF586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	C-Raf →	+0.229	+1.700	<.001	.042	3	2
UCEC	FoxM1 →	+0.285	+2.321	.007	.006	3	1
UCEC	FOXO3a_pS318_S321 →	-0.157	-2.105	.002	.017	3	1
UCEC	Acetyl-a-Tubulin-Lys40 →	+0.437	+2.179	.037	.034	3	1
UCEC	JNK2 →	+0.230	+2.331	.004	.019	3	1
UCEC	Ku80 →	+0.273	+3.594	.005	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 29 associations by consensus.

C-Raf by ZNF586 expression — UCEC

Explore this box plot interactively →