ZNF586

Across TCGA cell cohorts, ZNF586 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,189 significant associations in total. BLOOD_Lymphoma shows the largest number of these associations.

The most reproducible ZNF586-associated GO terms across cancer lineages are RNA catabolic process, Late viral transcription, and Positive regulation of transmembrane transport. Each is linked with ZNF586 in more than 11 cancer types. Because this analysis shows association rather than direction, both ZNF586-to-partner and partner-to-ZNF586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA catabolic process grouped by ZNF586-low versus ZNF586-high in LUNG_SCLC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF586→partner) and Y-score (partner→ZNF586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	RNA catabolic process →	+0.059	+0.686	<.001	.004	2	12
SOFT_TISSUE	Late viral transcription →	+0.104	+0.739	.001	<.001	3	10
LUNG_NSCLC_LUSC	Positive regulation of transmembrane transport →	-0.082	-1.365	.006	<.001	2	11
UPPER_AERODIGESTIVE_TRACT	Nucleic acid catabolic process →	+0.052	+0.830	.005	.004	2	11
SOFT_TISSUE	Regulation of double-strand break repair →	+0.066	+1.083	<.001	<.001	3	10
BLOOD_Leukemia	Regulation of RNA export from nucleus →	+0.095	+0.715	<.001	<.001	3	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,189 associations by consensus.

RNA catabolic process by ZNF586 expression — LUNG_SCLC

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