ZNF586

Across TCGA cell cohorts, ZNF586 mutation is significantly associated with the RNA expression of many other genes, with 43 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible ZNF586-associated genes across cancer lineages are PRMT8, H1-1, and GSC. Each is linked with ZNF586 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF586-to-partner and partner-to-ZNF586 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRMT8 grouped by ZNF586-low versus ZNF586-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF586→partner) and Y-score (partner→ZNF586) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	PRMT8 →	+0.020	+4.754	<.001	<.001	3	1
BLOOD_Myeloma	H1-1 →	+0.107	+3.906	<.001	.009	3	1
BLOOD_Myeloma	GSC →	+0.115	+4.285	.002	.003	3	1
BLOOD_Myeloma	NKX2-8 →	+0.088	+3.906	<.001	.009	3	1
BLOOD_Myeloma	OR13C5 →	+0.343	+3.906	.004	.009	3	1
LARGE_INTESTINE	STK11 →	+0.616	+3.215	.005	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

PRMT8 by ZNF586 expression — BLOOD_Myeloma

Explore this box plot interactively →