ZNF584

Across TCGA patient cohorts, ZNF584 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF584-associated genes across cancer lineages are ATM, eEF2, and ERK2. Each is linked with ZNF584 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF584-to-partner and partner-to-ZNF584 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by ZNF584-low versus ZNF584-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF584→partner) and Y-score (partner→ZNF584) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.666	-2.700	.001	.006	3	2
UCEC	eEF2 →	+0.337	+2.000	.036	.032	3	1
UCEC	ERK2 →	+0.224	+2.999	.009	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.238	-3.459	.001	.005	3	1
UCEC	MAPK_pT202_Y204 →	-0.612	-3.807	.003	<.001	3	1
UCEC	MEK1_p_S217_S221 →	-0.337	-3.584	.006	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ATM by ZNF584 expression — UCEC

Explore this box plot interactively →