ZNF584

Across TCGA pan-cancer cohorts, ZNF584 RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of ZNF584’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where ZNF584 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF584 is over-expressed in tumor, although a few such as KICH and THCA show the opposite, repressed pattern.

COAD, LIHC, and KICH are the cancer types where ZNF584 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF584 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	All	+0.759	<.001	10	view →
LIHC	Male	II,III,IV	+0.780	<.001	9	view →
KICH	Female	All	−0.782	<.001	6	view →
KIRP	All	II,III,IV	+0.356	.013	4	view →
CHOL	Male	All	+1.094	<.001	3	view →
HNSC	Male	All	+0.264	.020	3	view →
THCA	Male	II,III,IV	−0.247	.012	3	view →
READ	Male	All	+0.903	.017	2	view →
LUSC	Male	All	+0.292	.006	2	view →
STAD	All	II,III,IV	+0.365	.041	1	view →
KIRC	Female	All	+0.227	.039	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

ZNF584–COAD

Open the COAD breakdown →