ZNF582

Across TCGA patient cohorts, ZNF582 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF582-associated genes across cancer lineages are mTOR_pS2448, p27_pT198, and PCNA. Each is linked with ZNF582 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF582-to-partner and partner-to-ZNF582 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, mTOR_pS2448 grouped by ZNF582-low versus ZNF582-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF582→partner) and Y-score (partner→ZNF582) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	mTOR_pS2448 →	-0.176	-3.794	<.001	<.001	3	2
UCEC	p27_pT198 →	+0.095	+2.000	.008	.030	3	2
UCEC	PCNA →	+0.233	+1.514	.001	.015	3	2
UCEC	Rab25 →	-0.346	-3.584	.002	.002	3	2
UCEC	Shc_pY317 →	-0.161	-2.584	.001	.010	3	2
UCEC	Src_pY416 →	-0.183	-1.501	.025	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

mTOR_pS2448 by ZNF582 expression — UCEC

Explore this box plot interactively →