ZNF582

Across TCGA pan-cancer cohorts, ZNF582 RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of ZNF582’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF582 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF582 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and HNSC are the cancer types where ZNF582 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF582 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−0.903	<.001	12	view →
THCA	Male	IV	−0.863	<.001	11	view →
HNSC	Male	All	−0.511	<.001	11	view →
COAD	Male	All	−0.561	<.001	9	view →
LUSC	All	III,IV	−1.136	<.001	8	view →
LUAD	Female	III,IV	−0.806	<.001	8	view →
KICH	Male	All	−0.978	<.001	7	view →
KIRP	Male	III,IV	−0.956	<.001	7	view →
UCEC	All	III,IV	−1.275	<.001	6	view →
STAD	All	All	−0.546	<.001	6	view →
BRCA	Female	All	−0.291	<.001	6	view →
BLCA	All	IV	−0.655	.002	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

ZNF582–KIRC

Open the KIRC breakdown →