ZNF582-AS1

Across TCGA pan-cancer cohorts, ZNF582-AS1 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of ZNF582-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where ZNF582-AS1 RNA is repressed in tumor relative to normal tissue. In most cancer types ZNF582-AS1 is over-expressed in tumor, although a few such as KIRC and COAD show the opposite, repressed pattern.

KIRC, COAD, and BLCA are the cancer types where ZNF582-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF582-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	II,III,IV	−1.510	<.001	12	view →
COAD	Male	II,III,IV	−0.720	<.001	11	view →
BLCA	Male	IV	−1.790	<.001	10	view →
KICH	Male	II,III,IV	−1.562	<.001	10	view →
LUAD	Female	III,IV	−1.074	<.001	9	view →
LUSC	All	III,IV	−1.480	<.001	8	view →
HNSC	Male	All	−0.445	<.001	8	view →
KIRP	Male	II,III,IV	−1.567	<.001	7	view →
THCA	Male	III,IV	−0.517	.002	7	view →
UCEC	All	III,IV	−1.968	<.001	6	view →
BRCA	All	II,III,IV	−0.804	<.001	6	view →
STAD	All	All	−0.528	.003	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

ZNF582-AS1–KIRC

Open the KIRC breakdown →