ZNF581

Across TCGA pan-cancer cohorts, ZNF581 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated ZNF581 data layer compared with 28 for mass-spec protein and 5 for mutation status.

The strongest signal is observed in clear cell renal cell carcinoma (CCRCC), where higher ZNF581 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated ZNF581 expression acts as an unfavorable survival marker.

CCRCC, PDAC, and LUAD are the cancer types where ZNF581 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
CCRCC	DFS	Median	II,III,IV	0.094	1.000	.014	9	view →
PDAC	DFS	Tertile	All	0.219	0.965	.024	9	view →
LUAD	DFS	Median	II,III,IV	0.795	1.000	.024	4	view →
LSCC	OS	Quartile	II,III,IV	0.728	0.959	.043	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

ZNF581–CCRCC (DFS)

Open the CCRCC breakdown →