ZNF578

Across TCGA patient cohorts, ZNF578 mutation is significantly associated with the RNA expression of many other genes, with 3,135 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF578-associated genes across cancer lineages are SFPQP1, MIR383, and ARID3C. Each is linked with ZNF578 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF578-to-partner and partner-to-ZNF578 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SFPQP1 grouped by ZNF578-low versus ZNF578-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF578→partner) and Y-score (partner→ZNF578) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SFPQP1 →	+0.033	+1.808	<.001	.001	3	4
SKCM	MIR383 →	+0.034	+3.459	<.001	.008	3	3
SKCM	ARID3C →	+0.122	+1.981	.009	.007	3	3
LIHC	RNA5SP436 →	+0.107	+4.744	<.001	.002	3	3
UCEC	CENPU →	+0.625	+1.808	<.001	.007	3	3
UCEC	MIS18A →	+0.498	+1.584	.001	.005	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,135 associations by consensus.

SFPQP1 by ZNF578 expression — UCEC

Explore this box plot interactively →