ZNF561

Across TCGA patient cohorts, ZNF561 mutation is significantly associated with the RNA expression of many other genes, with 1,286 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF561-associated genes across cancer lineages are RNU6-1246P, RNU6-756P, and TRAJ57. Each is linked with ZNF561 in more than 3 cancer types. Because this analysis shows association rather than direction, both ZNF561-to-partner and partner-to-ZNF561 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-1246P grouped by ZNF561-low versus ZNF561-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF561→partner) and Y-score (partner→ZNF561) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	RNU6-1246P →	+1.377	+7.741	<.001	.009	3	4
BRCA	RNU6-756P →	+0.961	+6.442	<.001	.001	3	2
BRCA	TRAJ57 →	+0.764	+5.230	<.001	.007	3	2
BRCA	MDH1P2 →	+0.144	+5.175	<.001	.007	3	2
BRCA	RN7SKP221 →	+0.065	+7.471	<.001	.008	3	2
SKCM	RNA5SP379 →	+0.560	+4.058	<.001	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,286 associations by consensus.

RNU6-1246P by ZNF561 expression — COAD

Explore this box plot interactively →