ZNF561

Across TCGA pan-cancer cohorts, ZNF561 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of ZNF561’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where ZNF561 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types ZNF561 is over-expressed in tumor, although a few such as THCA and BRCA show the opposite, repressed pattern.

LIHC, THCA, and BRCA are the cancer types where ZNF561 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in ZNF561 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+0.919	<.001	7	view →
THCA	Male	II,III,IV	−0.751	<.001	7	view →
BRCA	Female	All	−0.340	<.001	6	view →
KICH	All	All	−0.771	<.001	5	view →
CHOL	Male	All	+1.936	<.001	3	view →
COAD	All	II,III,IV	+0.275	.015	3	view →
UCEC	All	All	−0.480	.018	2	view →
PAAD	Female	All	−0.344	.036	2	view →
LUAD	Female	All	+0.210	.045	1	view →
LUSC	All	All	+0.205	.016	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

ZNF561–LIHC

Open the LIHC breakdown →