ZNF561

Across TCGA patient cohorts, ZNF561 mutation is significantly associated with the total protein of many other genes, with 15 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF561-associated genes across cancer lineages are MEK1, MSH2, and p62 Lck ligand. Each is linked with ZNF561 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF561-to-partner and partner-to-ZNF561 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by ZNF561-low versus ZNF561-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF561→partner) and Y-score (partner→ZNF561) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.468	+3.459	.008	.005	3	1
UCEC	MSH2 →	-0.335	-2.459	.002	.020	3	1
UCEC	p62 Lck ligand →	+0.425	+3.179	.006	.010	3	1
UCEC	p70-S6K_pT389 →	-0.212	-2.999	.020	.035	3	1
UCEC	Annexin-1 →	+0.660	+3.019	.009	.019	3	1
UCEC	SF2 →	-0.134	-2.990	.011	.036	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

MEK1 by ZNF561 expression — UCEC

Explore this box plot interactively →