ZNF559-ZNF177

Across TCGA pan-cancer cohorts, ZNF559-ZNF177 Mutation is linked to patient survival in 3 of 34 cancer types, making it a survival-associated ZNF559-ZNF177 data layer compared with 19 for mass-spec protein.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher ZNF559-ZNF177 Mutation is associated with better disease-free survival. In most high-consensus cancer types, elevated ZNF559-ZNF177 expression acts as an unfavorable survival marker, although some lineages such as UCEC and LUSC show a favorable association.

UCEC, LUSC, and CHOL are the cancer types where ZNF559-ZNF177 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Median	All	1.000	0.629	.022	16	view →
LUSC	DFS	Median	II,III,IV	1.000	0.370	.031	4	view →
CHOL	OS	Median	All	0.155	0.725	.029	3	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

ZNF559-ZNF177–UCEC (DFS)

Open the UCEC breakdown →