ZNF558

Across TCGA patient cohorts, ZNF558 mutation is significantly associated with the RNA expression of many other genes, with 2,974 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible ZNF558-associated genes across cancer lineages are MCM8, PPIL4, and GNAT2. Each is linked with ZNF558 in more than 1 cancer types. Because this analysis shows association rather than direction, both ZNF558-to-partner and partner-to-ZNF558 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCM8 grouped by ZNF558-low versus ZNF558-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (ZNF558→partner) and Y-score (partner→ZNF558) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	MCM8 →	+0.785	+3.328	.006	.005	3	2
SKCM	PPIL4 →	+0.884	+3.341	.006	.005	3	2
SKCM	GNAT2 →	+0.017	+2.641	.006	.009	3	2
SKCM	MPHOSPH6 →	+0.625	+3.341	.005	.005	3	2
SKCM	CHEK1 →	+0.808	+3.328	.001	.005	3	2
SKCM	BOLA3 →	+0.565	+3.341	.001	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,974 associations by consensus.

MCM8 by ZNF558 expression — SKCM

Explore this box plot interactively →